Oncolytic adenovirus with increased proportion of 156R splicing isoform of E1B protein

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专利权人:

イクソゲン リミテッド

发明人:

エバーグ，ハンス，ダニエル,エバーグ,ハンス,ダニエル

申请号：

JP2015544539

公开号：

JP6388593B2

申请日:

2013.11.29

申请国别(地区):

JP

年份:

2018

代理人:

摘要：

The invention relates to a recombinant adenovirus that has an oncolytic effect in a cancer cell. By modulating the level and type of splice isoforms of the E1B gene product, expressed from the E1B gene, the oncolytic activity of such viruses can be enhanced. The invention provides a recombinant adenovirus in which the proportion of the E1B-156R isoform is increased relative to wild-type levels. Such a recombinant adenovirus may selectivity replicate in cancer cells, thereby killing cancer cells while sparing normal cells.

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中国工程科技知识中心

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http://www.ckcest.cn/home/