DEADMAN, JOHN,JONES, ERIC,LE, GIANG,RHODES, DAVID,THIENTHONG, NEERANAT,VAN DE GRAFF, NICHOLAS,WINFIELD, LISA
申请号：
ES09771849
公开号：
ES2459046T3
申请日:
2009.07.02
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of Formula I or a pharmaceutically acceptable hydrate, salt or prodrug thereof wherein: ** Formula ** A is a six-membered heteroaromatic or aromatic portion fused to the nitrogen-containing ring； L-R1 is 0-3 substituents wherein: each L is independently absent or is selected from the group consisting of Z, C1-3alkylene,>； C>； = Z, -CZ2-, -C (>； = Z) C1-3alkylene , -CZ2-C1-3alkylene, -C1-3alkylene-C (>； = Z) -, -C1-3alkylene-CZ2- where each Z is independently selected from O, S, and NH； each R1 is independently selected from the group consisting of hydrogen, C1-10alkyl wherein one or more of the carbon atoms of the alkyl chain may optionally be replaced with oxygen atoms, C1-10alkNR3R4, halo, NR3R4, alkylaryl, S ( O) NR3R4, SO2NR3R4, SO2C1-10alkyl, and C5-10cycloalkyl wherein one or more of the carbon atoms of the cycloalkyl ring are replaced with one or more oxygen atoms； R3 and R4 are each independently selected from the group consisting of hydrogen, C3-6cycloalkyl, C1-10alkyl, C1-10NR5R6, - (CO) (CO) NR5R6； or R3 and R4 taken together with the bound nitrogen form a 5-7 membered heterocyclic ring which contains from zero to two additional heteroatoms selected from N, O or S where S may be in the degree of oxidation S, S (O) or S (O) 2 and wherein said heterocyclic ring is optionally substituted on the carbon and nitrogen atoms with one or more substituents selected from halo, C1-4alkyl, CO2C1-4alkyl, NR5R6, C1-4alkylNR5R6 and additionally where one of the carbon atoms in the heterocyclic ring is optionally a carbonyl carbon； R5 and R6 are each independently selected from the group consisting of H and C1-4alkyl or R5 and R6 together with the attached nitrogen atom form a 5-7 membered heterocyclic ring which contains from zero to two additional heteroatoms selected from N , O or S where S may be in the degree of oxidation S, S (O) or S (O) 2 and wherein said heterocyclic ring is optionally substituted at the carbon and nitrogen atoms with one or mo
