ANDREW PAUL GARNER,CHRISTIAN CARSTEN SILVESTER KUNZ,ELIZABETH ANNE REISINGER SPRAGUE,NICOLE HAUBST,QING SHENG,SETH ETTENBERG,WINFRIED ELIS,XIZHONG HUANG
申请号：
BR112014013412
公开号：
BR112014013412A2
申请日:
2012.12.04
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract this invention relates to antibodies or fragments thereof which interact with her family of receptors, e.g., her3 receptor. in particular, it relates to antibodies or fragments thereof which recognize a conformational epitope of her3 receptor comprising residues from both domains 2 and 4 resulting in inhibition of both ligand-dependent and ligand-independent signal transduction； and allow ligand binding (e.g., neuregulin), while preventing ligand-induced activation of signal transduction. these antibodies or fragments can be used to treat a number of diseases or disorders characterized by increased levels of her3 expression (e.g., esophageal cancer). these antibodies or fragments can be used to treat a number of diseases or disorders characterized by the antibiotics or fragments ability to decrease tissue weight (e.g., prostate or uterine weights) or to induce atrophy of tissue (e.g., atrophy of male breast). *************************** Translation of the abstract patent summary: "antibodies to epidermal growth factor receptor 3 (her3)" . This invention relates to antibodies or fragments thereof that interact with her family receptors, for example, the her3 receptor. in particular, it refers to antibodies or fragments thereof that recognize a her3 conformational epitope comprising residues of both domains 2 and 4, resulting in inhibition of ligand-dependent and ligand-independent signal transduction； and allow ligand binding (e.g., neuregulin) while avoiding ligand-induced activation of signal transduction. Such antibodies or fragments thereof may be used to treat various diseases or disorders characterized by the ability of antibodies or fragments to decrease tissue weight (eg, prostate or uterine weights) or to induce tissue atrophy (eg, breast atrophy). male). 21442468v1 1/1 21442468v1abstract this invention relates to antibodies or fragments thereof which interact with her family of receptors, e.g., her3 receptor. in particular, it relates to antibodies
