ELIS WINFRIED,ETTENBERG SETH,GARNER ANDREW PAUL,HAUBST NICOLE,HUANG XIZHONG,KUNZ CHRISTIAN CARSTEN SILVESTER,REISINGER SPRAGUE ELIZABETH ANNE,SHENG QING
申请号：
IN5544/DELNP/2014
公开号：
IN2014DN05544A
申请日:
2014.07.04
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
This invention relates to antibodies or fragments thereof which interact with HER family of receptors e.g. HER3 receptor. In particular it relates to antibodies or fragments thereof that recognize a conformational epitope of HER3 receptor comprising residues from both domains 2 and 4 resulting in inhibition of both ligand dependent and ligand independent signal transduction and allow ligand binding (e.g. neuregulin) whilst preventing ligand induced activation of signal transduction. These antibodies or fragments can be used to treat a number of diseases or disorders characterized by increased levels of HER3 expression (e.g. esophageal cancer). These antibodies or fragments can be used to treat a number of diseases or disorders characterized by the antibodys or fragments ability to decrease tissue weight (e.g. prostate or uterine weights) or to induce atrophy of tissue (e.g. atrophy of male breast). Alternatively these antibodies or fragments can be used to treat a disorder characterized by increased levels of HER3 expression in an esophageal tract gastric cancer or head and neck cancer.
