A non-reusable syringe is provided. The syringe (10) comprises a barrel (11) adapted to contain a drug, the barrel (11) having a distal end wall portion (13) and a tubular wall (12) extending proximally from said distal end wall portion (13). The the barrel (11) extends along an axis (100), whereby the distal end wall portion (13) has an opening (14) extending into a syringe head (40) adapted to receive a syringe needle. The syringe (10) further comprises a plunger shaft (96) extending along the axis (100), the plunger shaft being displaceable along the axis (100) within said barrel (11) and a plunger (30) in a resilient material attached to a distal end of said plunger shaft (96). The plunger (30) is adapted to be in fluid-tight engagement with the tubular wall (12) of the barrel (11). The syringe further comprises a plunger stop (70) extending transversally from the tubular wall (12), said plunger stop (70) being adapted to stop movement of the plunger (30) solely in a direction extending proximally from the distal end wall portion (13).