PROBLEM TO BE SOLVED: To provide a controlled crystallization method of powder, in particular, spray-dried powder, for improving flowability and aerodynamic behavior thereof, and to provide a method for reducing the static electricity of the powder.SOLUTION: In a method of improving, achieving or minimizing reduction in flowability (FPF) of the powder containing an active substance, particularly a protein, and at least one kind of excipient, amorphous powder is exposed (i) over a defined exposure period, (ii) in a controlled manner to a water-containing gas or a solvent-containing gas with a defined relative humidity, (iii) at a defined temperature.COPYRIGHT: (C)2013,JPO&INPIT【課題】本発明は、粉末、特に噴霧乾燥粉末の流動性と空気力学的挙動を改善するための、該粉末の制御された結晶化、及び粉末の静電気を低減する方法に関する。【解決手段】活性物質、特にタンパク質と、少なくとも1種の賦形剤とを含有する粉末の流動性(FPF)の低減を改善、達成又は最小化する方法であって、非晶質粉末を、(i)規定曝露時間にわたって、(ii)規定相対湿度を有する水含有ガス又は溶媒含有ガスに制御様式で、(iii)規定温度にて曝露することを特徴とする前記方法。【選択図】図1
