TUMOR-TARGETING SYNTHETIC ADENOVIRUSES AND USES THEREOF

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专利权人:

Salk Institute for Biological Studies

发明人:

Clodagh O'Shea,Colin Powers,Lei Zhang

申请号：

US16434714

公开号：

US20190314523A1

申请日:

2019.06.07

申请国别(地区):

US

年份:

2019

代理人:

摘要：

Synthetic adenoviruses with liver detargeting mutations and expressing an adenovirus type 34 (Ad34) fiber protein, or a chimeric fiber protein with an Ad34 knob domain, are described. The synthetic adenoviruses traffic to sites of tumors. Use of the synthetic adenoviruses for delivering diagnostic or therapeutic transgenes to tumors are also described.

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