THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
WOOD, LAUREN V.,ROBERSON, BRENDA D.,BERZOFSKY, JAY A.,MORRIS, JOHN C.,STEEL, JASON C.,TERABE, MASAKI,BRENNER, MALCOLM K.
申请号：
CA3002685
公开号：
CA3002685A1
申请日:
2016.10.31
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Recombinant adenoviruses expressing the extracellular (EC) and transmembrane (TM) domains of human HER2 (HER2ECTM) are described. The recombinant adenoviruses express a chimeric fiber protein having the adenovirus type 35 (Ad5) shaft and knob domains, which facilitates transduction of human dendritic cells by the recombinant HER2ECTM expressing adenovirus. Compositions that include dendritic cells transduced by the recombinant adenovirus and their use for treating HER-positive tumors is described.
