CAMPBELL, JOHN EMMERSON,HEWITT, MICHAEL CHARLES,JONES, PHILIP,XIE, LINGHONG
申请号：
CA2800618
公开号：
CA2800618C
申请日:
2011.05.26
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Provided herein are compounds of formula A-L-B, and pharmaceuticallyacceptablesalts and stereoisomers thereof, wherein A isR1 and R2 together with the carbon atoms to which they are attached form a 1,2-phenylene ringoptionally substituted with one or more R11； L is ¨C(R6)2¨C(R6)2¨； B is aheteroaromaticgroup defined herein； and -A1-A2-, A3, R11 and R6 are defined herein. Alsodisclosed aremethods of their synthesis, pharmaceutical compositions comprising thecompounds, andmethods of their use. In one embodiment, the compounds provided herein areuseful for thetreatment, prevention, and/or management of various disorders, such as CNSdisorders andmetabolic disorders, including, but not limited to, e.g., neurologicaldisorders, psychosis,schizophrenia, obesity, and diabetes.(see above formula)
