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熱熔擠出式控釋劑型
专利权人:
GRUNENTHAL GMBH
发明人:
BARNSCHEID, LUTZ,GALIA, ERIC
申请号:
HK12108486.0
公开号:
HK1167811B
申请日:
2012.08.30
申请国别(地区):
HK
年份:
2015
代理人:
摘要:
The invention relates to a hot-melt extruded pharmaceutical dosage form with controlled release of a pharmacologically active ingredient (A) embedded in a matrix comprising a polymer (C), the dosage form exhibiting a breaking strength of at least 300 N and having an oblong shape comprising a longitudinal direction of extension, a transversal direction of extension orthogonal to the longitudinal direction of extension, a front side, an opposite back side and a circumferential rim between said front and back side; wherein the core of the pharmaceutical dosage form has a morphological orientation caused by hot-melt extrusion that is substantially orthogonal to the longitudinal direction of extension of the dosage form; and/or the release per area of the pharmacologically active ingredient (A) through the front side and the opposite back side is faster than the release through the circumferential rim.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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