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Hot-melt extruded pharmaceutical dosage form
专利权人:
Lutz Barnscheid
发明人:
Lutz Barnscheid,Eric Galia
申请号:
US12840439
公开号:
US10080721B2
申请日:
2010.07.21
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The invention relates to a hot-melt extruded pharmaceutical dosage form with controlled release of a pharmacologically active ingredient (A) embedded in a matrix comprising a polymer (C), the dosage form exhibiting a breaking strength of at least 300 N and having an oblong shape comprising a longitudinal direction of extension, a transversal direction of extension orthogonal to the longitudinal direction of extension, a front side, an opposite back side and a circumferential rim between said front and back sidewhereinthe core of the pharmaceutical dosage form has a morphological orientation caused by hot-melt extrusion that is substantially orthogonal to the longitudinal direction of extension of the dosage form and/or the release per area of the pharmacologically active ingredient (A) through the front side and the opposite back side is faster than the release through the circumferential rim.
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