A method for processing a sequence of a plurality of 2D projection images of an object of interest, acquired with a medical imaging system comprising a source of X-rays adapted to move around the object is provided. The method comprises obtaining 2D projection images of the object of interest according to a plurality of angulations at a first time when the object is without injection of a contrast product obtaining 2D projection images of the object of interest according to a plurality of angulations at a second time when the object is opacified by injection of a contrast product iteratively treating the projection images by minimizing relative to a sequence of 3D images, wherein the minimizing solution is a set of estimated 3D images.
