Disclosed is an antibody having properties described in the following (I) to (III) or a functional fragment thereof: (I) binding to the ROB04 protein with a KD value of 1 x 10-8 M or lower (II) suppressing or inhibiting vascular endothelial cell migration in the absence of a cross-linking antibody in vitro and (III) suppressing or inhibiting angiogenesis in vivo, wherein the antibody consists of a heavy chain comprising CDRHI consisting of the amino acid sequence represented by SEQ ID NO: 44 (Figure 25), CDRH2 consisting of the amino acid sequence represented by SEQ ID NO: 46 (Figure 26) or an amino acid sequence derived from the amino acid sequence of SEQ ID NO: 46 by the substitution of one amino acid, and CDRH3 consisting of the amino acid sequence represented by SEQ ID NO: 48 (Figure 27) , and a light chain comprising CDRLI consisting of the amino acid sequence represented by SEQ ID NO: 50 (Figure 28) or an amino acid sequence derived from the amino acid sequence of SEQ ID NO: 50 by the substitution of one to three amino acid(s), CDRL2 consisting of the amino acid sequence represented by SEQ ID NO: 52 (Figure 29) , and CDRL3 consisting of the amino acid sequence represented by SEQ ID NO: 54 (Figure 30) (sequences as defined in the specification)
