AEBI, JOHANNES,AMREIN, KURT,CHEN, WENMING,HORNSPERGER, BENOIT,KUHN, BERND,MAERKI, HANS P.,LIU, YONGFU,MAYWEG, ALEXANDER V.,MOHR, PETER,TAN, XUEFEI,WANG, ZHANGUO,ZHOU, MINGWEI
申请号：
PE2014000766
公开号：
PE20141283A1
申请日:
2012.11.27
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
It refers to bicycle derivatives in dihydroisocyano-1-ona (I) preparation process, wherein R1, R2, R3 and R4 are h, tar, cyclopentadiene, alcohole, etc.； A1 is CR8 or N； A5 is Cr6 or N, wherein R5, R6, R7 and R8 are each halogen, CN, halogen, hydroxyl, etc.； A2 is CR9 or N, wherein R9 is h, halogen, lalco, lallo, etc. Others； A3 is n, etc.； A4 is cr11 or N, R11 is h； n is 0 or 1. The most popular compounds are: 6-chloro-2-pyridine-3-il-3, 4-dihydro-2h-isoquinlin-1-ona； 5 - (6-chloro-1-oxo-3, 4-dihydro-1h-isoquinlin-2-il) - nicotine nitro；There are others He also mentioned an acquisition process and a drug synthesis. These compounds inhibit estraldehyde and are useful in the treatment of chronic kidney disease, congestive heart failure, hypertension and aldehyde poisoning.SE REFIERE A DERIVADOS BICICLICOS DE DIHIDROISOQUINOLIN-1-ONA DE FORMULA (I) DONDE R1, R2, R3 Y R4 SON CADA UNO H, ALQUILO, CICLOALQUILO, ALCOXIALQUILO, ENTRE OTROS； A1 ES CR8 O N； A5 ES CR6 O N, EN DONDE R5, R6, R7 Y R8 SON CADA UNO HALOGENO, CN, HALOALQUILO, HIDROXI, ENTRE OTROS； A2 ES CR9 O N, EN DONDE R9 ES H, HALOGENO, CN, ARILALQUILO, ENTRE OTROS； A3 ES N, ENTRE OTROS； A4 ES CR11 O N, EN DONDE R11 ES H； n ES 0 O 1. SON COMPUESTOS PREFERIDOS: 6-CLORO-2-PIRIDIN-3-IL-3,4-DIHIDRO-2H-ISOQUINOLIN-1-ONA； 5-(6-CLORO-1-OXO-3,4-DIHIDRO-1H-ISOQUINOLIN-2-IL)-NICOTINO-NITRILO； ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCESO DE OBTENCION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ALDOSTERONA SINTASA SIENDO UTILES EN EL TRATAMIENTO DE ENFERMEDADES RENALES CRONICAS, FALLO CARDIACO CONGESTIVO, HIPERTENSION, ALDOSTERONISMO
