AEBI, JOHANNES,AMREIN, KURT,CHEN, WENMING,HORNSPERGER, BENOIT,KUHN, BERND,MAERKI, HANS P.,LIU, YONGFU,MAYWEG, ALEXANDER V.,MOHR, PETER,TAN, XUEFEI,WANG, ZHANGUO,ZHOU, MINGWEI
申请号：
PE0007662014
公开号：
PE12832014A1
申请日:
2012.11.27
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to bicyclic Derivatives of dihidroisoquinolin - 1 - one of formula (i) wherein R1, R2, R3 and R4 are each h, alkyl, cycloalkyl, alkoxyalkyl esters, among others A1 and A5 is Cr6 CR8 N o n, where R5, R6, R7 and R8 are each Halogen CN, haloalquilo, Hydroxy, among others A2 is CR9 or n, e R9 n where is H, halogen, CN, arylalkyl, among others A3 is n, among others A4 is CR11 or n,Where R11 is h n is 0 OR 1. Preferred compounds are: 6 - Chloro - 2 - pyridin-3-yl - 3,4-dihydro - 2H - isoquinolin - 1 - One (6 - Chloro - 5 - 1 - oxo - 3,4-dihydro - 1H - isoquinolin - 2 - il) - Nicotinic acid among others. It also refers to a process of obtaining and to a Pharmaceutical composition.These compounds are inhibitors of the aldosterone synthase being useful in the treatment of Chronic Kidney Disease, congestive heart failure, hypertension, AldosteronismSE REFIERE A DERIVADOS BICICLICOS DE DIHIDROISOQUINOLIN-1-ONA DE FORMULA (I) DONDE R1, R2, R3 Y R4 SON CADA UNO H, ALQUILO, CICLOALQUILO, ALCOXIALQUILO, ENTRE OTROS A1 ES CR8 O N A5 ES CR6 O N, EN DONDE R5, R6, R7 Y R8 SON CADA UNO HALOGENO, CN, HALOALQUILO, HIDROXI, ENTRE OTROS A2 ES CR9 O N, EN DONDE R9 ES H, HALOGENO, CN, ARILALQUILO, ENTRE OTROS A3 ES N, ENTRE OTROS A4 ES CR11 O N, EN DONDE R11 ES H n ES 0 O 1. SON COMPUESTOS PREFERIDOS: 6-CLORO-2-PIRIDIN-3-IL-3,4-DIHIDRO-2H-ISOQUINOLIN-1-ONA 5-(6-CLORO-1-OXO-3,4-DIHIDRO-1H-ISOQUINOLIN-2-IL)-NICOTINO-NITRILO ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCESO DE OBTENCION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ALDOSTERONA SINTASA SIENDO UTILES EN EL TRATAMIENTO DE ENFERMEDADES RENALES CRONICAS, FALLO CARDIACO CONGESTIVO, HIPERTENSION, ALDOSTERONISMO
