Austin L. Gurney,Aaron Ken Sato,Fumiko Takada Axelrod,Timothy Charles Hoey,Sanjeev H. Satyal,Satyajit Sujit Kumar Mitra
申请号：
US13800801
公开号：
US20130295106A1
申请日:
2013.03.13
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Novel anti-cancer agents, including, but not limited to, antibodies and other polypeptides, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided. Screening methods are also provided.
