CHANG, Yun Sil,PARK, Won Soon,AHN, So Yoon,SUNG, Dong Kyung
申请号：
EP17892054
公开号：
EP3569238A4
申请日:
2017.10.31
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present invention relates to a pharmaceutical composition for preventing or treating neonatal hypoxic ischemic encephalopathy (HIE), comprising a thrombin-treated stem cell or an exosome derived therefrom as an active ingredient, and a method for producing the same. According to the present invention, the thrombin-treated stem cell or the exosome derived therefrom has an increased expression of growth factors, immunoregulatory factors, antioxidation factors, or regeneration factors compared to a group not treated with thrombin and also enhances a neuronal apoptosis inhibitory effect, and thus has an advantage in that the therapeutic effect thereof on neonatal hypoxic ischemic encephalopathy (HIE) is excellent.
