Composition for induction of adipocyte differentiation, regeneration of adipose tissue, skin whitening or wrinkle improvement containing exosomes derived from stem cells
The present invention relates to a pharmaceutical composition for inducing differentiation into an adipocyte and / or adipose tissue regeneration containing an exosome derived from a stem cell differentiated into an adipocyte as an active ingredient, wherein the exosome affects the differentiation into an adipocyte. It has an excellent expression rate of bioactive factors that give the ability to differentiate stem cells into adipocytes, which enables stem cell differentiation inducers, tissue regeneration injections, cosmetic fillers, tissue engineering preparations, etc. The present invention relates to a cosmetic composition for skin whitening, wrinkle improvement, or skin regeneration containing an exosome derived from stem cells as an active ingredient, and the exosome is a gene, protein associated with cell proliferation, differentiation, or regeneration of stem cells It is a purified component that contains growth factors, etc., and does not contain harmful agents of antibiotics, serum, or culture medium. Since a lipid mediator, skin whitening, wrinkle reduction, functional cosmetic composition comprising a skin regeneration can be applied to a improved formulation of scar cosmetic purposes. [Selection] Figure 7本発明は、脂肪細胞に分化されている幹細胞由来のエキソソームを有効成分として含有する脂肪細胞への分化誘導および／または脂肪組織再生用薬学的組成物に関し、前記エキソソームは脂肪細胞への分化に影響を与える生体活性因子の発現率に優れており、幹細胞を脂肪細胞に分化させる効果があり、これにより、幹細胞の分化誘導剤、組織再生用注射剤、美容目的のフィラー、組織工学用製剤などに適用でき、本発明は、幹細胞由来のエキソソームを有効成分として含有する皮膚美白、しわ改善、または皮膚再生用化粧料組成物に関し、前記エキソソームは幹細胞の細胞増殖、分化、再生に関連する遺伝子、タンパク質、成長因子などを含有しており、抗生剤や血清、培養液の有害因子が含まれていない精製された成分であり、細胞由来の脂質伝達体であるため、皮膚美白、しわ改善、皮膚再生を含む機能性化粧品組成物、美容目的の傷跡の改善製剤などに適用できる。【選択図】図７
