F. Anthony ROMERO,Thorsten A. KIRSCHBERG,Randall HALCOMB,Yingzi XU
申请号：
US16573860
公开号：
US20200087283A1
申请日:
2019.09.17
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided herein are compounds, preferably compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, compositions thereof, and methods of their preparation, and methods of inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, and methods for treating diseases wherein modulation of BCR-ABL1 activity prevents, inhibits, or ameliorates the pathology and/or symptomology of the disease.
