MJALLI, ADNAN M. M.,TIAN, YE EDWARD,WEBSTER, JEFFREY C.,ROTHLEIN, ROBERT
申请号：
CA2570324
公开号：
CA2570324C
申请日:
2005.08.03
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequenceslinked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilizea RAGE polypeptide domain comprising a RAGE ligand binding site and aninterdomain linker directly linked to an immunoglobulin CH2 domain. Suchfusion proteins may provide specific, high affinity binding to RAGE ligands.Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.
