Robillard Marc Stefan,Janssen Hendricus Marie,Ten Hoeve Wolter,Versteegen Ronny Mathieu,Rossin Raffaella
申请号：
US201214117655
公开号：
US9931408(B2)
申请日:
2012.05.16
申请国别(地区):
美国
年份:
2018
代理人:
摘要：
The invention relates to a Prodrug activation method, for therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention also relates to a Prodrug kit comprising at least one Prodrug and at least one Activator, wherein the Prodrug comprises a Drug and a first Bio-orthogonal Reactive Group (the Trigger), and wherein the Activator comprises a second Bio-orthogonal Reactive Group. The invention also relates to targeted therapeutics used in the above-mentioned method and kit. The invention particularly pertains to antibody-drug conjugates and to bi- and trispecific antibody derivatives.
