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BIO-ORTHOGONAL DRUG ACTIVATION
专利权人:
发明人:
申请号:
EP12725516.4
公开号:
EP2709668A1
申请日:
2012.05.16
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
The invention relates to a Prodrug activation method, for therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention also relates to a Prodrug kit comprising at least one Prodrug and at least one Activator, wherein the Prodrug comprises a Drug and a first Bio-orthogonal Reactive Group (the Trigger), and wherein the Activator comprises a second Bio-orthogonal Reactive Group. The invention also relates to targeted therapeutics used in the above-mentioned method and kit. The invention particularly pertains to antibody-drug conjugates and to bi- and trispecific antibody derivatives.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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