CALDARELLI MARINA M,ANGIOLINI MAURO M,COLOMBO RICCARDO R,DISINGRINI TERESA T,NUVOLONI STEFANO S,POSTERI HELENA H,SALSA MATTEO M,SILVAGNI MARCO M,.卡爾達萊利,.安吉奧利尼,.考洛姆伯,.迪辛格裡尼,.努沃羅尼,.波斯特裡,.薩爾薩,.希爾瓦戈尼
申请号：
HK11108487.0
公开号：
HK1154383B
申请日:
2011.08.12
申请国别(地区):
HK
年份:
2015
代理人:
摘要：
The present invention relates to pyrazolo-quinazolines, characterized by an ortho-substituted-arylamino, heterocyclylamino- or C3-C7 cycloalkylamino residue at 8 position and an aryl, heterocyclyl or C3-C7 cycloalkyl as substituent of a carboxamide at 3 position of the molecule framework. The compounds of this invention modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular MPS1/TTK. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
