Caldarelli, Marina,Angiolini, Mauro,Colombo, Riccardo,Disingrini, Teresa,Nuvoloni, Stefano,Posteri, Helena,Salsa, Matteo,Silvagni, Marco
申请号：
HRP20160243
公开号：
HRP20160243T1
申请日:
2016.03.08
申请国别(地区):
HR
年份:
2016
代理人:
摘要：
The present invention relates to pyrazolo-quinazolines, characterized by an ortho-substituted-arylamino, heterocyclylamino- or C3-C7 cycloalkylamino residue at 8 position and an aryl, heterocyclyl or C3-C7 cycloalkyl as substituent of a carboxamide at 3 position of the molecule framework. The compounds of this invention modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular MPS1/TTK. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
