This invention is about a preparation method of water soluble antimicrobial polyacrylate silver salt. The polyacrylate silver salt is synthesized by dissolving a acrylate polymer comprising sodium carboxylic group(-COONa) or potassium carboxylic group(-COOK) in water and exchanging the sodium carboxylic group or potassium carboxylic group of the acrylate polymer to silver carboxylic group(-COOAg) using silver salt in water solution. Then, Ultrafiltration member is used to remove the sodium salt or potassium salt generated from the metal ion exchanging procedure. The last step is to remove the water from the ultrafiltration treated water solution to give water soluble antimicrobial polyacrylate silver salt.本發明是有關一種水溶性抗菌壓克力高分子銀鹽之製備方法,此水溶性抗菌壓克力高分子銀鹽之合成係以含有羧酸鈉(-COONa)或羧酸鉀(-COOK)官能基團之壓克力高分子,利用此壓克力高分子之羧酸鈉或羧酸鉀官能基團和銀的鹽類在水中進行金屬離子交換,以得到含有羧酸銀(-COOAg)官能基團的水溶性壓克力高分子,然後再利用超過濾膜(Ultrafiltration membrane)將交換後產生的鈉鹽或鉀鹽去除,最後再將水去除以得到幾乎不含雜質的水溶性抗菌壓克力高分子銀鹽。