The present invention relates to a method and system for using a very large pore hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patients blood. One treatment includes the use of a very large pore hemofilter to remove target complex molecules and/or target molecules from a patients blood and to infuse a replacement fluid into the patients blood to maintain a prescribed albumin concentration in the patients blood.
