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Spiro-tetrahydro-benzothiophene derivatives useful for the treatment of neurodegenerative diseases
专利权人:
Ares Trading SA
发明人:
QUATTROPANI, Anna,SWINNEN, Dominique
申请号:
ES13722992
公开号:
ES2581540T3
申请日:
2013.05.10
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
Compound of formula (I) ** Formula ** in which X indicates a group selected from -S-CH2-, -SO-CH2, while Y indicates a group -CH2-, or alternatively XY together form a group - NR5-O-, -NR5-CO-, Q indicates a thiophene ring, L indicates a single bond or a group -NR5-CO-, U indicates a phenyl, pyridine or pyrimidine group, R1, R2, R3 are independently selected from each other of H, CN, halogen, Ar, Het, A, OA, SO2A, CO2A, O (CH2) Ar, or 2 of R1, R2 and R3 join together to form a 5 to 8-membered ring fused to the ring U and optionally containing 1 to 3 heteroatoms independently selected from O, N or S, Ra Rb are independently from each other H, A, Ar, (CH2) Ar, (CH2) Het, R5 is selected from H, A, ( CH2) -Ar, A is a linear or branched alkyl having 1 to 6 carbon atoms in which 1 to 6 hydrogen atoms can be independently substituted by a group selected from halogen, -O-C1-C6 alkyl, CN, Ar is an aromatic ring of 6 members that may be substituted with 1 to 3 groups selected from A, OA, phenyl, pyridine, CN, OH, CO2A, Het is a 4- to 8-membered heterocyclic ring containing 1 to 3 heteroatoms independently selected from O, S , N or CO, and optionally substituted with 1 to 3 groups selected from A, OA, phenyl, pyridine, CN, OH, CO2A, n is 0, 1 or 2, as well as enantiomers, diastereoisomers, tautomers thereof in all the reasons, and you leave them.Compuesto de fórmula (I)**Fórmula** en la que X indica un grupo seleccionado de -S-CH2-, -SO-CH2, mientras que Y indica un grupo -CH2-, o 5 alternativamente X-Y forman juntos un grupo -NR5-O-, -NR5-CO-, Q indica un anillo de tiofeno, L indica un enlace sencillo o un grupo -NR5-CO-, U indica un grupo fenilo, piridina o pirimidina, R1, R2, R3 se seleccionan independientemente entre sí de H, CN, halógeno, Ar, Het, A, OA, SO2A, CO2A, O(CH2)Ar, o 2 de R1, R2 y R3 se unen juntos para formar un anillo de 5 a 8 miembros condensado al anillo U y que contiene opcionalmente de 1 a 3 heteroátomos seleccionados independientemente de O, N o S, Ra Rb
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