Niki, Yoko,Yarosh, Daniel B.,Matsui, Mary S.,Yoshida, Masaki,Ichihashi, Masamitsu,Ando, Hideya
申请号：
AU2011203631
公开号：
AU2011203631A1
申请日:
2011.01.05
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Compositions and methods for lightening and/or depigmenting skin are provided, the compositions comprising compounds having the structure: Formula (I), wherein: R and R are same or different and are each selected from the group consisting of hydrogen, alkyl, carbomethoxy, carboethoxy, alkoxy, and alkanoyl, any of which may be halogen-substituted, and halogen R is selected from the group consisting of hydrogen, methyl, and ethyl and R, R and R are the same or different and are each selected from the group consisting of hydrogen, methyl, methoxy, ethoxy, methoxyethoxy, ethoxyethoxy, propoxy, propoxymethoxy, and the like, any of which may be halogen-substituted or having the structure: Formula (II), wherein: R is hydrogen, lower alkyl or hydroxy lower alkyl R is lower alkyl, -CHCN, hydroxy lower alkyl, -NO, -CHN=C or (wherein R and R are independently selected from the group consisting of hydrogen and lower alkyl) or hydrogen provided R is not hydrogen R is Z-T-W wherein Z represents -O-, -NH- or a single bond T represents a straight- or branched-chain lower-alkylene group when Z is a single bond, T also represents an ethenylene or a propenylene group wherein the unsaturated carbon is at the single bond when Z is -O-, T also represents an allylene group wherein the saturated carbon is at the oxygen and W represents hydrogen, when T is allylene and Z is -O-, and Ar, wherein Ar is selected from thienyl, pyridinyl, furanyl, phenyl and substituted phenyl wherein there are one or more substituents on the phenyl independently selected from halogen or lower alkyl and R is hydrogen, halogen or lower alkyl or pharmaceutically-, cosmetically- and dermatologically-acceptable salts, solvates, and bioprecursors, and stereoisomers and enantiomers of these compounds, free from or mixed with other enantiomers or stereoisomers and such compounds in compositions with a pharmaceutically-, cosmetically- or dermatologically-acceptable carrier thereof comprising a safe and effective amount
