Хэфнер, Родерик Питер,Лэйдлер, Пол,Хики, Паскаль,Лярш, Марк
申请号：
EA201492268
公开号：
EA201492268A1
申请日:
2013.05.30
申请国别(地区):
EA
年份:
2015
代理人:
摘要：
Pharmaceutical formulations that can be used to prevent or treat mold allergies of the genus Alternaria and / or Cladosporium containing a pharmaceutically acceptable carrier or diluent and a polypeptide or a pharmaceutically acceptable salt thereof selected from at least three: (a) a polypeptide containing the amino acid sequence WSWKIGPAIATGNT (Alt28； SEQ ID NO: 101) or containing a T-cell epitope variant sequence derived from the specified amino acid sequence, or its salt； (b) a polypeptide containing the amino acid sequence KYRRVVRAGVKVAQTAR (Alt34A； SEQ ID NO: 107) or containing a T cell epitope variant sequence derived from the specified amino acid sequence, or its salt； (c) a polypeptide containing the amino acid sequence KYAGVFVSTGTLGGG (SEQ ID NO: 112) or containing a T cell epitope variant sequence derived from the specified amino acid sequence, or its salt； (d) a polypeptide containing the amino acid sequence AEVYQKLKALAKKTYGQ (Alt13A； SEQ ID NO: 83) or containing a T cell epitope variant sequence derived from the specified amino acid sequence, or its salt； (e) a polypeptide containing the amino acid sequence SLGFNIKATNGGTLD (Alt01A； SEQ ID NO: 60) or containing a T-cell epitope variant sequence derived from the specified amino acid sequence, or its salt； (f) a polypeptide containing the amino acid sequence SAKRMKVAFKLDIEK (Alt06； SEQ ID NO: 72) or containing a T cell epitope variant sequence derived from the specified amino acid sequence, or its salt； (g) a polypeptide containing the amino acid sequence DITYVATATLPNYCR (SEQ ID NO: 111) or containing a T-cell epitopeФармацевтические составы, которые можно применять для профилактики или лечения аллергии на плесени рода Alternaria и/или Cladosporium, содержащие фармацевтически приемлемый носитель или разбавитель и полипептид или его фармацевтически приемлемую соль, выбранные по меньшей мере из трех: (а) полипептида, содержащего аминокислотную последовательность WSWKIGPAIATGNT (Alt28； SEQ ID NO: 101) или сод
