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RECURONIUM PREPARATION WITH IMPROVED STABILITY
专利权人:
LTD.;MARUISHI PHARMACEUTICAL CO.
发明人:
ITSUJI, YUTAKA,NAGAHARA, HIRONORI,JINBO, KEISUKE
申请号:
PH12016502418
公开号:
PH12016502418A1
申请日:
2016.12.02
申请国别(地区):
PH
年份:
2017
代理人:
摘要:
The present invention provides a rocuronium formulation having excellent stability. This formulation includes rocuronium and a buffer solution, and has a pH adjusted to 3.5 or less (for example, 2.5-3.5). The buffer solution may be a citric acid/sodium hydroxide buffer solution, a tartaric acid/sodium hydroxide buffer solution, a potassium hydrogen phthalate/hydrochloric acid buffer solution, a glycine/hydrochloric acid buffer solution or the like. This type of rocuronium formulation has a rocuronium analog C generation rate of 5 pcnt or less after being stored for six months at 40 oC, for example.
来源网站:
中国工程科技知识中心
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