PROBLEM TO BE SOLVED: To provide means for increasing an extraction rate of an active ingredient such as sialic acid and improving liquefaction effects and soluble components in the extraction from a swallow nest.SOLUTION: A swallow nest extraction method using a pressure and an enzyme in combination comprises a step of mixing a swallow nest, an enzyme, and water of a fixed ratio before conducting crushing homogenizing treatment to obtain a crude sample, a step of subjecting the crude sample after the crushing homogenizing treatment to high-pressure hydrolysis treatment at a pressure of 50-200 MPa to obtain a hydrolysate, and a step of subjecting the hydrolysate after the high-pressure hydrolysis treatment to separation treatment to obtain a hydrolytic extraction.COPYRIGHT: (C)2015,JPO&INPIT【課題】本発明は、燕の巣から抽出を行う際に、シアル酸等の活性成分の抽出率を増加させると共に、液化効果と可溶性成分を高めるための手段を提供する。【解決手段】本発明に係る圧力と酵素を併用した燕の巣の抽出方法は、燕の巣、酵素、及び一定の比率の水を混合した後に、破砕均質処理を行って粗サンプルを取得する工程と、破砕均質処理後の粗サンプルを50~200MPaの圧力にて高圧加水分解処理を行って加水分解物を取得する工程と、高圧加水分解処理後の加水分解物に対して分離処理を行って加水分解抽出物を取得する工程と、を含む。【選択図】図1