CROWLEY, MICHAEL M,KEEN, JUSTIN M,KOLENG, JOHN J,ZHANG, FENG
申请号：
NZ57220607
公开号：
NZ572206A
申请日:
2007.03.22
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed herein is a process for preparing a bioadhesive hot-melt coextruded laminate comprising a bioadhesive hydrophilic reservoir layer and a hydrophobic low permeability backing layer, the process comprising the step of: coextruding a thermoplastic hydrophilic first composition and a thermoplastic hydrophobic second composition to form the laminate, wherein the first composition comprises poly(ethylene oxide)； an active agent； and optionally one or more antioxidants, one or more lubricants, one or more hydrophobic polymers, one or more excipients, or a combination thereof, wherein the second composition comprises poly(ethylene oxide), at least one hydrophobic polymer； a plasticizer； and optionally one or more hydrophilic polymers, one or more excipients, or a combination thereof, wherein the second composition is hydrophobic, wherein the first and second compositions comprise at least one polymer in common. Also disclosed is a bioadhesive bi-layered hot-melt extruded laminate comprising a hydrophilic bioadhesive reservoir layer and a hydrophobic backing layer, wherein a) the reservoir layer comprises an active agent； b) the backing layer is hydrophobic； c) the reservoir layer and the backing layer both comprise poly(ethylene oxide) d) the laminate has (i) a uniform transverse cross-section throughout a majority of its length along its linear axis, and (ii) a uniform longitudinal cross-section throughout a majority of its transverse width； and e) the melt flow index of the reservoir layer is within 50% of the melt flow index of the backing layer.
