The Government of the United States of America; as represented by The Secretary; Department of Health and Human Services; National Institutes of Health
发明人:
FELBER, Barbara K.,PAVLAKIS, George N.
申请号：
AU2016216577
公开号：
AU2016216577B2
申请日:
2016.08.16
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2016216577B220180426.pdf#####ABSTRACT The present invention provides for nucleic acids improved for the expression of interleukin- 15 (IL- 15) in mammalian cells. The invention further provides for methods of expressing IL-15 in mammalian cells by transfecting the cell with a nucleic acid sequence encoding an improved IL-15 sequence. The present invention further provides expression vectors, and IL- 15 and IL- 15 receptor alpha combinations (nucleic acid and protein) that increase IL- 15 stability and potency in vitro and in vivo. The present methods are useful for the increased bioavailability and biological effects of IL-15 after DNA, RNA or protein administration in a subject (e.g. a mammal, a human). 53
