The Government of the United States; as represented by The Secretary of the Department of Health and Human Services; National Institutes of
发明人:
Pavlakis, George N.,Felber, Barbara K.
申请号：
AU2013203171
公开号：
AU2013203171B2
申请日:
2013.04.09
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2013203171B220160519.pdf#####ABSTRACT The present invention provides for nucleic acids improved for the expression of interleukin15 (JL-15) in mammalian cells. The invention further provides for methods of expressing IL15 in mammalian cells by transfecting the cell with a nucleic acid sequence comprising a codon optimized IL-15 sequence. The present invention further provides expression vectors, and IL-15 and IL-15 receptor alpha combinations (nucleic acid and protein) that increase IL15 stability and potency in vitro and in vivo. The present methods are useful for the increased bioavailability and biological effects of IL-15 after DNA, RNA or protein administration in a subject (e.g. a mammal, a human).
