DEKELVER, Russell,KRIVEGA, Ivan,MILLER, Jeffrey C.,ZHANG, Lei
申请号：
SG11202007440Y
公开号：
SG11202007440YA
申请日:
2019.02.08
申请国别(地区):
SG
年份:
2020
代理人:
摘要：
Described herein are engineered nucleases comprising mutations in the cleavage domain (e.g., FokI or homologue thereof) and/or DNA binding domain (zinc finger protein, TALE, single guide RNA) such that on-target specificity is increased.
