Russell DeKelver,Ivan Krivega,Jeffrey C. Miller,Lei Zhang
申请号：
US16271250
公开号：
US20190241877A1
申请日:
2019.02.08
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Described herein are engineered nucleases comprising mutations in the cleavage domain (e.g., FokI or homologue thereof) and/or DNA binding domain (zinc finger protein, TALE, single guide RNA) such that on-target specificity is increased.
