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Tricyclic Derivatives of quinolinas and quinoxalinas
专利权人:
ABBVIE INC.;ABBVIE DEUTSCHLAND GMBH & CO. KG
发明人:
WILFRIED BRAJE,MARGOT BAKKER,CAROLIN HOFT,KARLA DRESCHER,HELMUT MACK,ANDREAS HAUPT,ANA LUCIA RELO,HANNES KOOLMAN,RUXU XU,XIAONA ZHAO,VIKTOR LAKICS
申请号:
ARP130103294
公开号:
AR092568A1
申请日:
2013.09.13
申请国别(地区):
AR
年份:
2015
代理人:
摘要:
Claim 1: A compound characterized in that it is of the formula (1) where G is (CR³ᵃR³ᵇ) ₙ;X is 8310 or cr8311; r831222;R¹ is selected from the group consisting of hydrogen, cyano, C₁₋₆ alkyl,C₁₋₆ fluorinated alkyl, C₂₋₆ alkenyl,C₂₋₆ fluorinated alkenyl, C₂₋₆ alkynyl,C₂₋₆ fluorinated alkynyl, C₃₋₈ cycloalkyl,C₃₋₈ fluorinated cycloalkyl, C₁₋₆ alkoxy,Alcoxi c83218c8331-832626 fluorination, - C (= O) r1-83044;phenyl, phenyl-C₁₋₂ alkyl and a saturated, partially unsaturated or fully unsaturated heterocyclic ring of 3, 4, 5, 6, 7 or 8 members containing 1, 2, 3 or 4 heteroatoms or heteroatom groups independently selected from N, O, S, NO, SO and SO₂ and optionally also 1 or 2 groups C = O and / or C = S as ring members, where the cyclic units in the last three radicals mentioned can be substituted with one or more substituents R¹¹;each R² is independently selected from the group consisting of cyano, nitro, C₁₋₆ alkyl,C₁₋₆ fluorinated alkyl, C₁₋₆ hydroxyalkyl,C₂₋₆ alkenyl,C₂₋₆ fluorinated alkenyl, C₂₋₆ alkynyl,C₂₋₆ fluorinated alkynyl, C₃₋₈ cycloalkyl,C₃₋₈ fluorinated cycloalkyl, C₁₋₆ alkoxy,fluorinated C₁₋₆ alkoxy, C₁₋₆-C₁₋₄ alkoxy,C₁₋₆ hydroxy-alkoxy,C₁₋₆ alkoxy-C₁₋₄ alkoxy,1. C8332121 asphalt;fluorinated C₁₋₆ alkylthio, C₁₋₆sulfinyl alkyl, fluorinated C₁₋₆sulfinyl alkyl, C₁₋₆sulfonyl alkyl, fluorinated C₁₋₆sulfonyl alkyl, -NR¹²ᵃR¹²ᵇ,-Ch8322; - No. 74191; - R2 74955;-74191st; (c) R1830404,-C (3DO) RSO NR RC₁₋₆carbonyloxy alkyl, fluorinated C₁₋₆carbonyloxy alkyl, phenyl, phenylC₁₋₂ alkyl,Phenyl, phenylsulfur, phenyl and a saturated, partially or completely unsaturated, unsaturated or unsaturated ring, consisting of 3, 4, 5, 6, 7 or 8 members, including 1, 2, 3 or 4 heteroprotons or heteroatom groups independently selected from n, O, s, no, so, so, so, so 8322;C = O and C = s are ring members. In the ring, the periodic units of the last six matrices can be replaced by one or more R1 substitutes;R³ᵃ and R³ᵇ,Independent of each other,are selected from the group consisting of
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