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БУФЕРНЫЕ ГЛАЗНЫЕ КОМПОЗИЦИИ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
专利权人:
ХИЛОР ЛТД. (IL)
发明人:
ТЕННЕНБАУМ Тамар (IL),БРЕЙМАН-УИКСМАН Лиора (IL),САГИВ Ювал (IL),ЛЕВИ-ХАЧАМ Офра (IL)
申请号:
RU2013117209/15
公开号:
RU2013117209A
申请日:
2011.11.08
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. Formula izobreteniyaGlaznaya composition vklyuchayuschayaa) 0.1-2.0% (w / v) sodium chloride.. B) 0,01-0,5% (w / v) potassium chloride.. C) 0, 01-1,0% (w / v..) of sodium acetate trihydrate d) 0,01-1,0% (w / v) trisodium citrate dihydrate.. e) water, and f) one or more pharmaceutically active agents. 2. Ophthalmic composition according to Claim. 1, wherein the composition comprises 0.6-0.8% (wt. / Vol.) Sodium hlorida.3. Ophthalmic composition according to Claim. 1, wherein the composition comprises 0.07-0.09% (wt. / Vol.) Of potassium hlorida.4. Ophthalmic composition according to Claim. 1, wherein the composition comprises 0.3-0.5% (wt. / Vol.) Trigidrata.5 sodium acetate. Ophthalmic composition according to Claim. 1, wherein the composition comprises 0.1-0.3% (wt. / Vol.) Digidrata.6 trisodium citrate. Ophthalmic composition according to Claim. 1, wherein the composition has a pH from about 5.5 to about 8.0 or from about 6.8 to 7,6.7. Ophthalmic composition according to claim. 6, wherein the composition has a pH of about 7,2.8. Ophthalmic composition according to Claim. 1, wherein the composition has an osmolality from 220 to 320 mOsm / kg.9. Ophthalmic composition according to Claim. 1, wherein the composition has an osmolality of about 300 mOsm / kg.10. Ophthalmic composition according to Claim. 1, wherein the composition has a viscosity of about 1 to 50000 sP.11. Ophthalmic composition according to Claim. 1, wherein the pharmaceutically active agent is selected from the group consisting of anesthetics, astringents, antihypertensives, antiglaucoma, neuroprotective, anti-allergic, reinforcing sekretsiyuslizi, angiostatic, anti-microbial, anti-inflammatory or analgesic sredstva.12. Ophthalmic composition according to claim. 11 wherein the pharmaceutical active agent is selected from the group consisting of a polypeptide, an oligonucleotide, a hormone, chemical compound or lipid.13. Ophthalmic composition according to Claim. 1, wherein the pharmaceutically acti
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