Universite Montpellier 2 Sciences Et Techniques;Idenix Pharmaceuticals, Inc.;Centre National De La Recherche Scientifique
发明人:
Gilles Gosselin,Christophe Claude Parsy,François-René Alexandre,Houcine Rahali,Jean-François Griffon,Dominique Surleraux,Cyril B. Dousson,Claire Pierra,Adel M. Moussa,Benjamin Alexander Mayes,Alistair
申请号：
US14920830
公开号：
US20160083413A1
申请日:
2015.10.22
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2′-chloro nucleosides according to Formula 2001:or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein B, Z and PD are as described herein.
