Disclosed are bis (thio－hydrazide amide) disalts, which are represented by Structural Formula (I):Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R1－R4are independently－H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or R1and R3taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2and R4taken together with the carbon and nitrogen atoms to which they are bonded, form a non－aromatic heterocyclic ring optionally fused to an aromatic ring. Z is－O or－S. M＋is a pharmaceutically acceptable monovalent cation and M2＋is a pharmaceutically acceptable divalent cation.Also, disclosed are pharmaceutical compositions comprising a bis (thio－hydrazide amide) disalt described above. Further disclosed are methods of treating a subject with cancer. The methods comprise the step of administering an effective amount of a bis (thio－hydrazide amide) disalt described above.本發明係揭示雙（硫醯肼醯胺）二鹽，其由結構式(I)所代表：Y是共價鍵或經取代或未經取代之直鏈氫碳基。R1－R4獨立為－H、脂肪基、經取代的脂肪基、芳基或經取代的芳基，或R1和R3與其所鍵結的碳及氮原子結合在一起，和/或R2和R4與其所鍵結的碳及氮原子結合在一起形成非芳香族雜環，其視需要與芳環融合。Z是－O或－S。M＋是醫藥上可接受的單價陽離子並且M2＋是醫藥上可接受的二價陽離子。同時，本發明亦揭示包含以上所說明的雙（硫醯肼醯胺）二鹽之醫藥組成物。本發明還揭示治療罹患癌症的患者之方法。該方法包括施用有效量之以上所說明的雙（硫醯肼醯胺）二鹽之步驟。
