Alpha amino acid derivatives and pharmaceuticals containing them as active ingredients

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专利权人:

日産化学工業株式会社;中外製薬株式会社

发明人:

生頼 一彦,安達 倫明,外山 公二,清水 孝紀,林 圭史,南 昌孝,鈴木 好幸,杉山 昌一,大田 雅照,門野 正次郎,白石 拓也,佐藤 晴彦,渡辺 佳晃,石井 暢也,堺谷 政弘,長谷川 雅巳

申请号：

JP2008522646

公开号：

JP5258563B2

申请日:

2007.06.29

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

The present invention provides novel ±-amino acid derivatives of formula (1): (wherein, R 1 , R 2 , R 3 , R 4 , X and Y are as defined in the claims) or pharmaceutically acceptable salts, prodrugs or solvates thereof. The derivatives of formula (1) have ²ARK1 inhibitory activity and are useful for preventing or treating heart failure. Moreover, the derivatives of formula (1) also have antitumor activity, particularly dual inhibitory activity on Aurora kinase and CDK, and are useful for cell proliferative diseases such as cancer.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/