alpha-AMINO ACID DERIVATIVE AND PHARMACEUTICAL COMPRISING THE SAME AS ACTIVE INGREDIENT

• 收藏
• 分享

专利权人:

NISSAN CHEMICAL INDUSTRIES; LTD.

发明人:

OHRAI, KAZUHIKO,ADACHI, MICHIAKI,TOYAMA, KOJI,SHIMIZU, TAKANORI,HAYASHI, KEISHI,MINAMI, MASATAKA,SUZUKI, YOSHIYUKI,SUGIYAMA, MASAKAZU,OHTA, MASATERU,KADONO, SHOJIRO,SHIRAISHI, TAKUYA,SATO, HARUHIKO,WA

申请号：

EP07767879

公开号：

EP2045253A4

申请日:

2007.06.29

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

The present invention provides novel α-amino acid derivatives of formula (1):(wherein, R1, R2, R3, R4, X and Y are as defined in the claims) or pharmaceutically acceptable salts, prodrugs or solvates thereof. The derivatives of formula (1) have βARK1 inhibitory activity and are useful for preventing or treating heart failure. Moreover, the derivatives of formula (1) also have antitumor activity, particularly dual inhibitory activity on Aurora kinase and CDK, and are useful for cell proliferative diseases such as cancer.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/