Pharmaceutical composition that can form an emulsion in contact with an aqueous environment, comprising a system for administering self-emulsifying drugs of reine or diacerein, or salts or esters or prodrugs thereof in one or more pharmaceutically acceptable carriers, comprising one or more Emulsifiers selected from the group consisting of polyoxyethylene glycerol esters of fatty acids, polyoxylated castor oil, ethylene glycol esters, propylene glycol esters, fatty acid glyceryl esters, polyglyceryl esters, fatty alcohol ethoxylates, propoxylated ethoxylated block copolymers, of polyethylene glycol of fatty acids, polyethoxylated castor oil, monocaprylate or glycerol caprate, and one or more pharmaceutically acceptable polymers, wherein the pharmaceutically acceptable polymer is selected from the group consisting of cellulosic polymers or their derivatives including hydroxypropyl methylcellulos a, hydroxymethyl cellulose, hydroxyethyl cellulose, methyl cellulose, hydroxypropyl cellulose, sodium carboxymethyl cellulose, carboxymethyl cellulose, polyacrylate / polyalcohol copolymers, gums, polyacrylate / polyacrylamide copolymers, polyvinyl alcohol polymers, polyvinyl methacrylamide copolymers polyamino acids, polysaccharidesComposición farmacéutica que puede formar una emulsión en contacto con un entorno acuoso, que comprende un sistema de administración de fármacos autoemulsionante de reína o diacereína, o sales o ésteres o profármacos de las mismas en uno o más vehículos farmacéuticamente aceptables, que comprende uno o más emulsionantes seleccionados del grupo que consiste en ésteres de polioxietilenglicerol de ácidos grasos, aceite de ricino polioxilado, ésteres de etilenglicol, ésteres de propilenglicol, ésteres de glicerilo de ácidos grasos, ésteres de poliglicerilo, etoxilatos de alcoholes grasos, copolímeros de bloque propoxilados etoxilados, ésteres de polietilenglicol de ácidos grasos, aceite de ricino polietoxilado, monocaprilato o caprato de glicerol, y u
