DISCLOSED IS A PERCUTANEOUS ABSORPTION PREPARATION OF DONEPEZIL USED AS A PLASTER TO SKIN, WHICH COMPRISES AT LEAST AN ADHERENT LAYER (5), AN INTERMEDIATE MEMBRANE (4), AND A DRUG RESERVOIR LAYER (3) SEQUENTIALLY FROM THE SIDE WHICH IS PLASTERED ON SKIN, WHEREIN SAID DRUG RESERVOIR LAYER (3) COMPRISES DONEPEZIL OR A SALT THEREOF A DIALKYLAMINOALKYL (METH)ACRYLATE-ALKYL(METH)ACRYLATE COPOLYMER A POLYHYDRIC ALCOHOL SELECTED FROM A SUGAR ALCOHOL AND A GLYCOL A CARBOXYLIC ACID ESTER SELECTED FROM AN ALKYL CITRATE ESTER AND AN ALKYL SEBACATE ESTER A SORBITAN FATTY ACID ESTER AND A (METH)ACRYLATE-VINYL ESTER COPOLYMER, SAID INTERMEDIATE MEMBRANE (4) IS A MICROPOROUS MEMBRANE HAVING PORES WHICH ALLOW PERMEATION OF DONEPEZIL, AND SAID ADHERENT LAYER (5) ENABLES THE PLASTERING OF THE PERCUTANEOUS ABSORPTION PREPARATION TO SKIN, IS PERMEABLE TO DONEPEZIL, AND COMPRISES A CARBOXYLIC ACID ESTER SELECTED FROM AN ALKYL CITRATE ESTER AND AN ALKYL SEBACATE ESTER A SORBITAN FATTY ACID ESTER AND A (METH)ACRYLATE-VINYL ESTER COPOLYMER.
