A pulse diagnosis measurement device comprises a sensing device, for sensing a blood pressure wave of an organism, to generate a pulse signal; a pulse-pressing device, for applying a pressure on a pulse position of the organism, wherein the pulse-pressing device has an elasticity coefficient, the elasticity coefficient is corresponding to a frequency of a harmonic of the blood pressure wave, and the harmonic is a integer harmonic or a fractional harmonic; and a processing device, for generating pulse diagnosis information of the harmonic according to the pulse signal.一種脈診量測裝置,包含有一感測器,用來感測一生物體的一血壓波,以產生一脈波訊號;一壓脈裝置,用以施加一壓力於該生物體之脈搏,其中該壓脈裝置具有一彈性係數,該彈性係數對應於該血壓波的一諧波的頻率,該諧波為一整數諧波或一分數諧波;以及一處理器,用以依據該脈波訊號,產生該諧波的脈診資訊。