GELFANOVA, VALENTINA PAVLOVNA,HALE, JOHN EDWARD,KIKLY, KRISTINE KAY,WITCHER, DERRICK RYAN,RATHNACHALAM, RADHAKRISHNAN
申请号：
CA2452447
公开号：
CA2452447C
申请日:
2002.08.15
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Human monoclonal antibodies that specifically bind to TNFSF13b polypeptidesare disclosed. These antibodies have high affinity for hTNFSF13b (e.g., KD =10-8 M or less), a slow off rate for TNFSF13b dissociation (e.g., Koff = 10-3sec-1 or less) and neutralize TNFSF13b activity in vitro and in vivo. Theantibodies of the invention are useful in one embodiment for inhibitingTNFSF13b activity in a human subject suffering from a disorder in whichhTNFSF13b activity is detrimental. Nucleic acids encoding the antibodies ofthe present invention, as well as, vectors and host cells for expressing themare also encompassed by the invention.
