Ludzkie przeciwcialo przeciw hTNFSF13b, izolowany kwas nukleinowy, rekombinowany wektor ekspresji, kompozycja farmaceutyczna oraz takie przeciwcialo do zastosowania jako lek i do zastosowania w leczeniu
GELFANOWA VALENTINA PAVLOVNA,HALE JOHN EDWARD,KIKLY KRISTINE KAY,WITCHER DERRICK RYAN,RATHNACHALAM RADHAKRISHNAN,R
申请号：
PL37053402
公开号：
PL212404B1
申请日:
2002.08.15
申请国别(地区):
PL
年份:
2012
代理人:
摘要：
Human monoclonal antibodies that specifically bind to TNFSF13b polypeptides are disclosed. These antibodies have high affinity for hTNFSF13b (e.g., K D = 10 -8 M or less), a slow off rate for TNFSF13b dissociation (e.g., K off = 10 -3 sec -1 or less) and neutralize TNFSF13b activity in vitro and in vivo. The antibodies of the invention are useful in one embodiment for inhibiting TNFSF13b activity in a human subject suffering from a disorder in which hTNFSF13b activity is detrimental. Nucleic acids encoding the antibodies of the present invention, as well as, vectors and host cells for expressing them are also encompassed by the invention.
