AS REPRESENTED BY THE SECRETARY;THE GOVERNORS OF THE UNIVERSITY OF ALBERTA;THE GOVERNMENT OF THE UNITED STATES OF AMERICA;THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
KNAUS, EDWARD E.,VELAZQUEZ, CARLOS A.,SHOWALTER, BRETT,KEEFER, LARRY,SAAVEDRA, JOSEPH E.
申请号：
AU2007244903
公开号：
AU2007244903B2
申请日:
2007.04.24
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Disclosed are compounds that release nitric oxide, e.g., a compound of Formula (I) wherein R, X, and n are as described herein, which are NSAID derivatives comprising a diazeniumdiolate moiety NO The compounds are chemopreventive agents with gastric-sparing, analgesic, cardioprotective, and/or anti-inflammatory properties. Also disclosed is a pharmaceutical composition comprising a compound of the invention and a pharmaceutically acceptable carrier. Also disclosed is a method of preventing or treating cancer or treating inflammation or an inflammation-related condition in a mammal comprising administering an effective amount of a compound of the invention to the mammal.
