PURPOSE: A zebra fish model for inflammatory diseases and a method for screening an anti-inflammatory agent using the same are provided to screen effective anti-inflammatory agent without side effects. CONSTITUTION: A method for screening an anti-inflammatory agent using zebra fish model comprises: a step of treating one selected from the group consisting of lipopolysaccharides, oxidized low-density lipoprotein, and saccharification apolipoprotein to the zebra fish； and a step of administering a candidate drug to the zebra fish and evaluating the development and apoptosis of an embryo. The inflammatory diseases are inflammatory dermatitis, glomerulus nephritis, inflammatory bowel disease, inflammatory collagen vascular disease, osteoarthritis, inflammatory eye disease, IgA nephropathy, rheumatoid arthritis, post-vaccinal encephalomyelitis, and diabetes.본 발명은 염증성 질환용 제브라피쉬 모델 및 이를 이용한 항염증제의 스크리닝 방법에 관한 것으로, 보다 상세하게는 제브라피쉬에 지질다당류(LPS), 산화된 저밀도지단백(oxidized Low Density Lipoprotein, oxLDL) 및 당화 아포지단백(gA-I)으로 이루어진 군에서 선택된 어느 하나의 물질을 처리하여 얻어진 새로운 염증성 질환용 제브라피쉬 모델을 이용하여 항염증제를 효과적으로 스크리닝할 수 있다.
