The device has a penetration device comprising an arrangement of application tools (1, 2), which are coupled to an operating mechanism. The application tools are displaceable relative to each other between an initial position and a penetration position by the operating mechanism. An effect direction of application force provided by one application tool is counter to an effect direction of the application force provided by another application tool during the relative movement of the application tools. An independent claim is also included for a method for applying an active ingredient on or into an organic tissue.